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Cell Biology · Lesson 3 of 12

Nucleus

You want to bake your grandmother's cookies, but the old recipe book stays safe on a high shelf. You do not bring the book over to the messy counter with the flour and eggs. You write the steps onto a small card and take that card to the mixing bowl. You can smudge the card, and the original book is still clean. If you spill milk on the card, you simply copy the steps out again.

Nucleus — Where the Instructions Are Kept
Plate. Nucleus — a round center with pores.

The nucleus holds the cell's DNA, which carries the instructions for building proteins. Working copies of those instructions, called messenger RNA, pass out through tiny pores in the membrane. The rest of the cell reads the copies and builds what it needs. This is where the memory line stops being true, because the nucleus is not a boss giving orders. The memory line says, "The nucleus keeps the instructions. The cell does the work." But signals from outside the nucleus trigger which instructions get copied, and some cells live without a nucleus entirely. A mature red blood cell pushes its nucleus out so it can pack in more oxygen.

Therefore

Do not look for a boss inside a cell. Look at the chemistry passing back and forth between the parts instead.

Robert Brown, 1831

In 1831, the Scottish botanist Robert Brown was studying orchids under his microscope in London. He peeled the thin surface skin from an orchid leaf and looked closely at the cells. In every cell, he noticed a round spot in the center. Other botanists had seen the spot before, but Brown realized it was in almost every plant cell he checked. In November of 1831, he read a paper to the Linnean Society of London. He named the spot the nucleus, from the Latin word for a little nut or kernel.

A small reminder, on a laptop lid or a binder, that keeping the instructions safe matters only because the rest of the cell reads them.

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